Meanwhile, Luca Marini is now fastest with a 1m 47.9s, 0.7s ahead of Jorge Martin with Marc Marquez in an early third.
Brad Binder is the first MotoGP faller of the weekend, running wide at the tight turn 1 and then toppling in the gravel. He's trying to get his KTM back to the pits.
Misano double winner Jorge Martin is the early session leader, already several seconds under the Moto2 best.
Aprilia's Aleix Espargaro tests the gravel by running wide at Turn 1.
Nightmare start for replacement Michele Pirro who falls on his out lap at Turn 5. The Italian was running off line and looking back when he was caught out.
The green lights are on and FP1 begins.
Stand-out sections of the challenging 5km circuit include the long, banked turns 8-9 and the undulating 1km back straight.
After Thursday evening's downpour, track conditions are fully dry with air temperatures already over 30-degrees for MotoGP's opening practice session at the Buddh International Circuit.